Skip to the content
2023
“Discovery of Aptamers Against Cell Surface Markers Using Ligand-Guided Selection ”, Williams, N., Patel, R., Mallikaratchy, P.: (Invited book chapter)”; Nucleic Acid Aptamers. Methods in Molecular Biology, Eds: Mayer, G., Menger, M.M.: Humana: (2570) p. 13-38: 2023.
2021
“A bispecific aptamer sensor towards T-cell leukemia detection in the tumor microenvironment” , Boykoff, N.; Freage, L.; Lenn, J.; Mallikaratchy, P.R.; ACS Omega, 2021: 6(48):32563-32570, Pre-print DOI: 10.26434/chemrxiv-2021-2hztc.“The utility of multivalent artificial nucleic acid ligands to develop nanoscale DNA devices against surface receptors” , Freage, L.; Boykoff, N.; and Mallikaratchy, P.R.; (Invited review) ACSOmega, 2021: 6(19):12382-12391.
2020
“A Homodimeric Aptamer Variant Generated from Ligand-Guided Selection Activates the T Cell Receptor Cluster of Differentiation 3 Complex” , Freage L.; Jamal, D.; Williams, N. and Mallikaratchy, P.R.; Mol. Therapy Nucleic Acids, 2020: 22:167-178, Pre-print DOI: https://doi.org/10.1101/2020.05.18.102145.“Homodimeric variant of an aptamer generated from LIGS activates TCR-CD3ε Complex” , Freage, L.; Jamal, D.; and Mallikaratchy, P.; bioRxiv, 2020.05.18.102145.“Ligand Guided Selection (LIGS) with Artificially Expanded Genetic Information Systems against TCR-CD3ε” , Zumrut, H.; Yang, Z.; Williams, N.; Arizala, J. D. R.; Batool, S.; Benner, S.; Mallikaratchy, P. R.; Biochemistry, 2020: 59(4): 552-562.“Discovery of artificial nucleic acid ligands against cell surface targets”, Zumrut, H.; Mallikaratchy, P.R.; (Invited spotlight) ACS Applied Biomaterials, 2020: 3(5):2545-2552.
2019
“Discovery of artificial nucleic acid ligands against cell surface targets”, Zumrut, H.; Mallikaratchy, P.R.; ACS Appl. Bio Mater., 2019.
“Integrating Ligand-receptor Interactions and In Vitro Evolution for Streamlined Discovery of Artificial Nucleic Acid Ligands” , Zumrut, H.; Batool, S.; Argyropoulos, K.; Williams, N.; Azad, R.; Mallikaratchy, P.R.; Mol. Therapy Nucleic Acids, 2019: 6(17):150-163.“The key role of G-quadruplex structures in anti-IgM aptamers-target specific recognition”, Moccia F.; Platella C.; Musumeci D.; Batool S.; Zumrut H.; Bradshaw J.; Mallikaratchy P.R.; Montesarchio D., Biochem. Biophys. Acta. General topics, 2019: 133:839-849.
US Patent: 10253314: Prabodhika Mallikaratchy; “Ligand-guided-selection method for screening antigen-specific ligands ”; Date granted: April 09, 2019.
“Synthesis of stable azide and alkyne functionalized phosphoramidite nucleosides” , Lingala, S.; Nordstrøm L.U.; Mallikaratchy, P.R., 2019; Tetrahedron Lett, 17: 60(3):211-213.“Dimerization of an aptamer generated from Ligand-guided Selection (LIGS) yields highly specific scaffold with improved affinity” , Batool, S.; Argyropoulos, K.; Azad, R.; Okeoma, P.; Zumrut, H.; Dekhang, R.; Mallikaratchy, P.R.; Biochem. Biophys. Acta. General topics, 2019: 1863(1):232-240.
2018
“Dimerization of an aptamer generated from Ligand-guided selection (LIGS) yields a high affinity scaffold against B-cells” , Batool, S.; Argyropoulos, K.V.; Azad, R.; Okeoma, P.; Zumrut, H.; Bhandari, S.; Dekhang, R.; Mallikaratchy, P.; Biochimica et Biophysica Acta (BBA)-General Subjects: 2018, 1863 (1), 232-240, doi:10.1016/j.bbagen.2018.10.006.“Conformational behaviour and molecularity of novel anti-IgM G-quadruplex forming aptamers”, Moccia, F.; Musumeci, D.; Platella, C.; Bradshaw, J.; Mallikaratchy, P.; Montesarchio, D.;2 018 August 19.
“Ligand-guided selection (LIGS): A SELEX variant to identify specific aptamers against cell-surface markers”, Zumrut, H.; Batool, S.; Argyropoulos, K.; Dekhang, R.; Mallikaratchy‚ P.; 2018 August 19.
“Design of a dimeric aptamer against B-cell receptor”, Batool, S.; Zumrut, H.E.; Bhandari, S.; Van, N.; George, S.; Mallikaratchy‚ P.; 2018 March 18. 255th ACS National Meeting.
2017
“Modification of 2’-OMe RNA analogues enhances the stability of an aptamer evolved against Myeloid Leukemia cells” , Maio, G.E.; Enweronye, O.; Zümrüt, H.E.; Batool, S.; Van, N.; Mallikaratchy, P.R.; ChemistrySelect, 2017: 2(7):2335-2340.“Engineered Aptamers to Probe Molecular Interactions on the Cell Surface” , Batool, S.; Bhandari, S.; George, S.; Okeoma, P.; Van, N.; Zumrut, H.E.; and Mallikaratchy, P.; Biomedicines: 2017 Aug 29;5(3). pii: E54. doi:10.3390/biomedicines5030054.“Structural optimization of an aptamer generated from Ligand guided Selection (LIGS) resulted in high affinity variant toward mIgM expressed on Burkitt’s lymphoma cell lines” , Zumrut, H.E.; Batool, S.; Van, N.; George, S.; Bhandari, S.; Mallikaratchy, P.; Biochimica et Biophysica Acta (BBA)-General Subjects: 2017 July 01; 1861(7):1825-1832. pii: S0304-4165(17)30111-3. doi:10.1016/j.bbagen.2017.03.020.“Optimization of structure of an aptamer discovered utilizing Ligand Guided Selection (LIGS) yields high affinity aptamer”, Zumrut, H.E.; Batool, S.; Van, N.; Mallikaratchy, P.; 2017 April 2.
“Evolution of complex target SELEX to identify aptamers against mammalian cell surface antigens” , Mallikaratchy, P.R.; (Invited review) Special Topical Collection: New Frontiers in Nucleic Acid Chemistry Molecules, 2017: 22(2):E215.
2016
“Ligand-guided selection of aptamers against T-cell Receptor-cluster of differentiation 3 (TCR-CD3) expressed on Jurkat.E6 cells” , Zümrüt, H.E.; Ara, N.; Maio, G. E.; Van, N.; Batool, S.; Mallikaratchy, P.R.; Anal. Biochem., 2016: 512:1-7.“Evolution of Complex Target SELEX to Identify Aptamers against Mammalian Cell-Surface Antigens” , Mallikaratchy, P.; Molecules: Jan 30;22(2). pii: E215. doi:10.3390/molecules22020215.“Designing bispecific aptamers for increased stability in human serum”, Maio, G.; Zumrut, H.; Van, N.; Batool, S.; Mallikaratchy, P.; 2016 August 20.
“Ligand-guided selection (LIGS): A screening technology to identify specific aptamers against cell-surface markers” Mallikaratchy, P.; 2016 August 20.
“Ligand-Guided Selection of Target-Specific Aptamers: A Screening Technology for Identifying Specific Aptamers Against Cell-Surface Proteins” , Zümrüt, H.E.; Ara, N.; Fraile, M.; Maio, G.E.; Mallikaratchy, P.R.; Nucleic Acid Ther., 2016: 26(3):190-198.
2015
Prabodhika Mallikaratchy, Hasan Zumrut, Naznin Ara. Discovery of Biomarkers Using Aptamers Evolved in Cell-SELEX Method‚ Aptamers selected by cell-SELEX for Theranostics‚ Principles, Eds. W. Tan and X. Fan, SpringerLink. 2015; p.265.
2013
“A self-assembling short oligonucleotide duplex suitable for pretargeting” , Mallikaratchy, P.R.; Gardner, J.R.; Nordström, L.U.R.; Veomett, N.J.; McDevitt, M.R.; Heaney, M.L.; and Scheinberg, D.A.; Nucleic Acids Therapeutics, Volume: 23 Issue 4: July 31, 2013.“Discovery of Biomarkers Using Aptamers Evolved in Cell-SELEX Method” , Mallikaratchy, P.R.; Zümrüt, H.E.; Ara, N.; (Invited book chapter); Aptamers selected by cell-SELEX for Theranostics; Principles, Eds. W. Tan and X. Fan; SpringerLink: p. 265-299: 2015.
2011
“A multivalent DNA aptamer specific for the B cell receptor on human lymphoma and leukemia” , Mallikaratchy, P.R.; Ruggiero, A.; Gardner, J.R.; Kuryavyi, V.; Maguire, W.F.; Heaney, M.L.; McDevitt, M.R.; Patel, D.J.; Scheinberg, D.A.; Nucleic Acids Res., 2011: 39(6):2458-2469.
2009
“Multivalent DNA Aptamer-Based Therapeutic Agents for Lymphoma and Leukemia” , Mallikaratchy, P.; Ruggiero, A.; Maguire, W.; Piersanti, K.; Gardner, J.; Villa, C.; Escorcia, F.; Palomba, M.L.; Heaney, M.; McDevitt, M.R.; Scheinberg, D.A.; Blood: 2009 November 20, 114(22);2711-2711.“BIOT 288-Multivalent DNA aptamer-based therapeutic agents for lymphoma”, Mallikaratchy, P.; Scheinberg, D.; 2009 August 16, 238th ACS National Meeting.
“Fluorescent Aptamer Sensors‚ Functional Nucleic Acids for Analytical Applications”, Chen, H.W.; Kim, Y.; Meng, L.; Mallikaratchy, P.; Martin, J.; Tang, Z.; Shangguan, D.; O’Donoghue, M.; Tan, W.; 2009; 111-130.
“Using aptamers evolved from cell-SELEX to engineer a drug delivery platform”, Mallikaratchy, P.R.; Liu, H.; Huang, Y.-F.; Wang, H.; Lopez-Colon, D.; Tan, W.; Chem. Commun., 2009: (21):3056-3058.
2008
“Aptamer switch probe based on intramolecular displacement” , Tang, Z.; Mallikaratchy, P.R.; Yang, R.; Kim, Y.; Zhu, Z.; Wang, H.; Tan, W.; J. Am. Chem. Soc., 2008: 130(34):11268-11269.“Aptamers evolved from whole cell selection as a selective anti-tumor photodynamic agent”, Mallikaratchy, P.R.; Tang, Z.; Tan, W.; ChemMedChem: Chemistry Enabling Drug Discovery, 2008: 3(3):425-428.
“Cell-specific aptamer probes directing cancer biomarker discovery in cancer cells”, Shangguan, D.; Meng, L.; Mallikaratchy, P.R.; Li, Y.; Tan, W.; J. Proteomic Res., 2008: 7(5):2133-2139.
“Cell specific aptamer‚ photosensitizer conjugates as a molecular tool in photodynamic therapy” , Mallikaratchy, P.; Tang, Z.; Tan, W.; ChemMedChem: Chemistry Enabling Drug Discovery, 2008 March 14; 3(3), 425-428, doi: 10.1002/cmdc.200700260.“In Vitro Selection and Development of Aptamers for Biomarker Discovery and Targeted Therapy”, Mallikaratchy, P.; ProQuest: 2008.
2007
“Aptamer directly evolved from live cells recognize membrane bound immunoglobin heavy mu chain on Burkitt’s lymphoma cells” , Mallikaratchy, P.R.; Tang, Z.; Kwame, S.; Meng, L.; Shangguan, D.; Tan, W.; Mol. Cell. Proteomics., 2007: 6(12):2230-2238.“Selective antitumor aptamer-photodynamic agent conjugates as a tool in photochemo therapy”, Mallikaratchy, P.; Tan, W.; 2007 August 19, 234.
“DNA aptamers for molecular imaging and profiling of cancer” , Mallikaratchy P.R.; Chen, H.; Tang, Z.; Meng, L.; Shangguan, D.; Parekh, P.; Kim, Y.; Sefah, K.; Tan, W.; American Pharm. Rev., 2007: 10(6): 134.“Selection of aptamers for molecular recognition and characterization of cancer cells” , Tang, Z.; Shangguan, D.; Wang, K.; Kwame, S.; Mallikaratchy, P.R.; Li, Y.; Tan, W.; Anal. Chem., 2007: 79(13): 4900-4907.“Optimizations and modifications of aptamers selected from live cancer cells”, Shangguan, D.; Tang, Z.; Mallikaratchy P.R.; Xiao, Z.; Tan W.; ChemBioChem., 2007: 8(6):603-606.
“Fluorescent Aptamer Probes”, Chen, H.; Kim, Y.; O’Donoghue, M.; Mallikaratchy, P.R.; Martin, J.; Tang, Z.; Shangguan, D.; and Tan, W.; Functional Nucleic Acid Sensors Based on Different Transduction Principles; Eds. Yi Lu and Yingfu Li; SpringerLink: p. 111-130: 2007.
2005
“Cancer cell proteomics using molecular aptamers” Tan, W.; Cao, Z.; Shangguan, D.; Li, Y.; Tang, Z.; Mallikaratchy, P.R.; Chen, H.; Drug Discovery Handbook; Ed. Shayne Cox Gad; Wiley-Inter science: p. 73-86: 2005.
“Facile Access to novel organotellurium heterocycles by nitration of Bis- (3, 5-Dimethylphenyl) Ditelluride”, Mallikarachy P.R.; Fronczek F.R.; Brotherton H.O.; Junk T.; J. Het. Chem., 2005: 42(2): 243-247.
“(μ-Diazenediyldiphenyl-κ2C2, N2: κ2C2′, N1) bis [(3, 5-dimethylphenyl) tellurium (II)]” , Mallikaratchy, P.; Norman, R.E.; Fronczek, F.R.; Junk, T.; Acta. Crystallographica. 2005; E61 (7): m1370.
